قرين جسم مضاد-دواء

مخطط يوضح تركيب قرين جسم مضاد-دواء

تعد قرائن الأجسام المضادة والأدوية (بالإنجليزية: Antibody–drug conjugates أو ADCs)‏ فئة من الأدوية الصيدلانية الحيوية المصممة علاجا موجها لعلاج السرطان.[1] على عكس العلاج الكيميائي، تهدف قرائن الأجسام المضادة والأدوية إلى استهداف الخلايا السرطانية وقتلها مع الحفاظ على الخلايا السليمة. حتى عام 2019، كانت هناك حوالي 56 شركة أدوية تقوم بتطوير الأدوية مكونة من قرائن الأجسام المضادة والأدوية.[2]

إن قرائن الأجسام المضادة والأدوية عبارة عن جزيئات معقدة تتكون من جسم مضاد مرتبط بحمولة أو عقار نشط بيولوجيًا سام للخلايا (مضاد للسرطان).[3] تعتبر قرائن الأجسام المضادة والأدوية مثالاً على القرائن الحيوية والقرائن المناعية.

تجمع قرائن الأجسام المضادة والأدوية بين خصائص الاستهداف للأجسام المضادة وحيدة النسيلة وقدرات الأدوية الكيمياوية السامة للخلايا على قتل السرطان، والمصممة للتمييز بين الأنسجة السليمة والمريضة.[4][5]

المصادر

  1. ^ Hamilton GS (Sep 2015). "Antibody–drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids". Biologicals (بالإنجليزية). 43 (5): 318–32. DOI:10.1016/j.biologicals.2015.05.006. PMID:26115630. Archived from the original on 2023-03-28.
  2. ^ Matsuyama K (11 Jun 2019). "Drug to replace chemotherapy may reshape cancer care". BNN Bloomberg (بالإنجليزية). Archived from the original on 2024-01-27. Retrieved 2019-06-14.
  3. ^ Fitzpatrick-Dimond PF (9 Mar 2010). "Antibody-Drug Conjugates Stage a Comeback". GEN: Genetic Engineering and Biotechnology News (بالإنجليزية). Archived from the original on 2023-03-28.
  4. ^ DiJoseph JF, Armellino DC, Boghaert ER, Khandke K, Dougher MM, Sridharan L, et al. (Mar 2004). "Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies". Blood (بالإنجليزية). 103 (5): 1807–14. DOI:10.1182/blood-2003-07-2466. PMID:14615373. S2CID:17543492.
  5. ^ Mullard A (May 2013). "Maturing antibody–drug conjugate pipeline hits 30". Nature Reviews. Drug Discovery (بالإنجليزية). 12 (5): 329–32. DOI:10.1038/nrd4009. PMID:23629491. S2CID:28757488.


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