عامل إثارة القص

عامل إثارة القص أو عامل التحفيز على القص (بالإنجليزية: Cleavage stimulation factor)‏ (CstF) هو مركب بروتين ثلاثي متغاير يتكون من البروتينات: CSTF1 (55 كد) وCSTF2 (64 كد) وCSTF3 (77 كد) بمجموع حوالي 200 كيلو دالتون. وظيفته المساهمة في قص المنطقة المشفِّرة 3' من جزيئات الرنا قبل الرسول المخلقة حديثا.يُوظَّف المركب CstF بواسطة العامل المتخصص بالقص وعديد الأدينيلات (CPSF) ويتكتلان في مركب بروتيني على النهاية 3' لتحفيز تخليق ذيل عديد الأدينيلات، فينتج عن ذلك رنا رسول ناضج جاهز للتصدير خارج النواة إلى العصارة الخلوية لتتم ترجمته.

تعتمد كمية البروتين CstF في الخلية على دورتها، حيث تزداد بشكل معتبر أثناء الانتقال من الطور G0 إلى طور التركيب في الخلايا الليفية اليافعة للفأر والخلايا البائية البشرية.[1]

روابط خارجية

مراجع

  1. ^ Martincic، K.؛ Campbell، R.؛ Edwalds-Gilbert، G.؛ Souan، L.؛ Lotze، M. T.؛ Milcarek، C. (1998). "Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition". Proceedings of the National Academy of Sciences of the United States of America. ج. 95 ع. 19: 11095–11100. DOI:10.1073/pnas.95.19.11095. PMC:21601. PMID:9736695.
  • Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipursky SL, Darnell J. (2004). Molecular Cell Biology. WH Freeman: New York, NY. 5th ed.
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