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Chuan-Pu Lee

Chuan-pu Lee
Lahir1931
Qingdao, Shandong, China
Meninggal20 Juli 2016
Detroit, Michigan, US
PekerjaanAhli biokimia, profesor universitas

Chuan-pu Lee (1931 – 2016) adalah seorang ahli biokimia Amerika, kelahiran Tiongkok. Ia berprofesi sebagai profesor biokimia di Fakultas Kedokteran Universitas Negeri Wayne dari tahun 1975 hingga pensiun pada tahun 2011. Ia dilantik ke dalam Hall of Fame Wanita Michigan pada tahun 2000.

Kehidupan awal dan pendidikan

Chuan-pu Lee lahir di Qingdao, Provinsi Shandong, Tiongkok. Ia bersama lima saudaranya lahir dari pasangan Fung-Hwa Lee dan Wei-Ping Liu Lee.[1] Semasa pendidikannya ia memperoleh gelar sarjana kimia dari Universitas Nasional Taiwan pada tahun 1954, dan berhasil menyelesaikan studi doktoral di Universitas Negeri Oregon pada tahun 1961, di bawah profesor pembimbing Tsoo E. King, dengan disertasinya yang berjudul "Biochemical Studies of Western Ring Spot Virus".[2] Adik laki-lakinya Chuan-kuo Lee juga menerima gelar master dari Universitas Pennsylvania dalam bidang fisika.[3]

Karir

Chuan-pu Lee pernah memegang posisi postdoktoral di Universitas Pennsylvania yang bekerja bersama Britton Chance, dan kemudian menjadi profesor biokimia fisik di sana. Ia merupakan profesor biokimia di Fakultas Kedokteran Universitas Negeri Wayne mulai tahun 1975.[4] Ia juga memiliki perhimpunan dengan Universitas Stockholm melalui kolaboratornya, Lars Ernster. Penelitiannya melibatkan bioenergi mitokondria atau penelitian tentang bagaimana energi diproduksi dalam tubuh pada tingkat sel. Penelitiannya dipublikasikan di beberapa jurnal akademik termasuk Annual Review of Biochemistry,[5] European Journal of Biochemistry,[6] FEBS Letters,[7] Journal of Neurochemistry,[8] Methods in Enzymology,[9] dan Biochemistry.[10] Pada tahun 2011 ia pensiun dari jabatannya.[11]

Pada tahun 2000 Chuan-pu Lee diangkat ke Hall of Fame Wanita Michigan.[12][13] Ia mendirikan beasiswa Chuan-Pu Lee, Ph.D. Endowed Graduate Student Research Fund di Universitas Negeri Wayne, yang memberikan dana bagi mahasiswa pascasarjana untuk menopang kebutuhan akademiknya.[14]

Publikasi

Chuan-pu Lee telah menulis lebih dari 200 artikel ilmiah dalam jurnal baik secara sendiri maupun bersama rekannya. Beberapa karyanya yang terpilih sejak tahun 1964 hingga 2005 adalah:

  • "Biological Oxidoreductions" (bersama Lars Ernster, terbit tahun 1964).[5]
  • "Properties of mitochondria isolated from herring gull salt gland" (bersama Britton Chance, Reiko Oshino, and George D. V. Van Rossum tahun 1964).
  • "Stereochemistry of hydrogen-transfer in the energy-linked pyridine nucleotide transhydrogenase and related reactions" (bersama L. Ernster, N. Simard-Duquesne, dan H. D. Hoberman tahun 1965).[15]
  • "Energy-coupling in nonphosphorylating submitochondrial particles" (bersama L. Ernster tahun 1967).[9]
  • "Studies of the Energy-Transfer System of Submitochondrial Particles" (bersama L. Ernster tahun 1968).[6]
  • "Comparison of fluorescence probe and light-scattering readout of structural states of mitochondrial membrane fragments" (bersama Britton Chance tahun1969).[7]
  • "Ion transport and energy conservation in submitochondrial particles" (bersama Britton Chance dan Maurice Montal tahun 1970).[16]
  • "Oxidation-reduction potentials of cytochromes in mitochondria" (bersama P. Leslie Dutton dan David Franklin Wilson tahun 1970).[10]
  • "Progressive Ophthalmoplegia, Glycogen Storage, and Abnormal Mitochondria" (bersama Salvatore DiMauro, Donald L. Schotland, Eduardo Bonilla, Pierluigi Gambetti, dan Lewis P. Rowland tahun 1973).
  • "Neuromuscular Disorder Associated With a Defect in Mitochondrial Energy Supply" (bersama Donald L. Schotland, Salvatore DiMauro, Eduardo Bonilla, dan Antonio Scarpa tahun 1976).
  • "Tightly coupled beef heart submitochondrial particles" (1979).[17]
  • "Reye's syndrome: salicylates and mitochondrial functions" (bersama Margaret E. Martens tahun 1984).[18]
  • "Mitochondrial Encephalomyopathies" (bersama Margaret E. Martens dan Patti L. Peterson tahun 1988).[19]
  • "The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain" (bersama Ye Xiong, Feng-Shiun Shie, Jing Zhang, dan Ye-Shih Ho tahun 2004).[20]
  • "Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase" (bersama Ye Xiong, Feng-Shiun Shie, Jing Zhang, dan Ye-Shih Ho).[8]

Kehidupan pribadi

Chuan-pu Lee meninggal di rumah sakit di Detroit pada tahun 2016 diusianya yang ke-84 tahun.[11][14] Untuk mengenang jasanya, Universitas Negeri Wayne mengadakan acara tahunan yang diberi nama Chuan-Pu Lee, Ph.D. Endowed Graduate Student Research Presentation Day.[21]

Referensi

  1. ^ "Chuan-Shue (Mike) Lee". The News Journal. 2019-08-09. hlm. A12. Diakses tanggal 2022-01-31. 
  2. ^ "Chemistry Tree - Chuan-Pu Lee". academictree.org. Diakses tanggal 2022-01-31. 
  3. ^ "Chang-kuo Lee, PHD". The News Journal. 2015-03-01. hlm. A33. Diakses tanggal 2022-01-31. 
  4. ^ Rzepka, Marianne (1980-03-19). "China Visit is Going Home for 2 WSU Profs". Detroit Free Press. hlm. 2. Diakses tanggal 2022-01-31. 
  5. ^ a b Ernster, L; Lee, C P (1964-06-01). "Biological Oxidoreductions". Annual Review of Biochemistry. 33 (1): 729–788. doi:10.1146/annurev.bi.33.070164.003501. ISSN 0066-4154. 
  6. ^ a b Lee, Chuan-pu; Ernster, L. (1968). "Studies of the Energy-Transfer System of Submitochondrial Particles". European Journal of Biochemistry (dalam bahasa Inggris). 3 (4): 391–400. doi:10.1111/j.1432-1033.1967.tb19542.x. ISSN 1432-1033. 
  7. ^ a b Chance, Britton; Lee, Chuan-pu (1969). "Comparison of fluorescence probe and light-scattering readout of structural states of mitochondrial membrane fragments". FEBS Letters (dalam bahasa Inggris). 4 (3): 181–184. doi:10.1016/0014-5793(69)80229-2. ISSN 1873-3468. 
  8. ^ a b Xiong, Ye; Shie, Feng-Shiun; Zhang, Jing; Lee, Chuan-Pu; Ho, Ye-Shih (2005). "Prevention of mitochondrial dysfunction in post-traumatic mouse brain by superoxide dismutase". Journal of Neurochemistry (dalam bahasa Inggris). 95 (3): 732–744. doi:10.1111/j.1471-4159.2005.03412.x. ISSN 1471-4159. 
  9. ^ a b Lee, Chuan-pu; Ernster, Lars (1967-01-01). [87] Energy-coupling in nonphosphorylating submitochondrial particles. Oxidation and Phosphorylation (dalam bahasa Inggris). 10. Academic Press. hlm. 543–548. 
  10. ^ a b Dutton, P. Leslie; Wilson, David Franklin; Lee, Chuan-Pu (1970-12-01). "Oxidation-reduction ptoentials of cytochromes in mitochondria". Biochemistry. 9 (26): 5077–5082. doi:10.1021/bi00828a006. ISSN 0006-2960. 
  11. ^ a b "Dr. Chuan-Pu Lee dies at age 84". School of Medicine News (dalam bahasa Inggris). 2019-03-08. Diakses tanggal 2022-01-31. 
  12. ^ "Chuan-Pu Lee". Michigan Women Forward (dalam bahasa Inggris). Diakses tanggal 2022-01-31. 
  13. ^ "Women's Hall of Fame Center Plans for Picnic". Detroit Free Press. 2001-06-05. hlm. 29. Diakses tanggal 2022-01-31. 
  14. ^ a b "Dr. Chuan-Pu Lee Obituary (1931 - 2016) The News Journal". Legacy.com. Diakses tanggal 2022-01-31. 
  15. ^ Lee, Chuan-Pu; Simard-Duquesne, N.; Ernster, L.; Hoberman, H. D. (1965-01-01). "Stereochemistry of hydrogen-transfer in the energy-linked pyridine nucleotide transhydrogenase and related reactions". Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation (dalam bahasa Inggris). 105 (3): 397–409. doi:10.1016/S0926-6593(65)80226-0. ISSN 0926-6593. 
  16. ^ Montal, Maurice; Chance, Britton; Lee, Chuan-pu (1970-12-01). "Ion transport and energy conservation in submitochondrial particles". The Journal of Membrane Biology (dalam bahasa Inggris). 2 (1): 201–234. doi:10.1007/BF01869861. ISSN 1432-1424. 
  17. ^ Lee, Chuan-pu (1979-01-01). [12] Tightly coupled beef heart submitochondrial particles. Biomembranes Part F: Bioenergetics: Oxidative Phosphorylation (dalam bahasa Inggris). 55. Academic Press. hlm. 105–112. 
  18. ^ Martens, Margaret E.; Lee, Chuan-Pu (1984-09-15). "Reye's syndrome: Salicylates and mitochondrial functions". Biochemical Pharmacology (dalam bahasa Inggris). 33 (18): 2869–2876. doi:10.1016/0006-2952(84)90209-0. ISSN 0006-2952. 
  19. ^ Peterson, Patti L.; Martens, Margaret E.; Pu Lee, Chuan (1988-08-01). "Mitochondrial Encephalomyopathies". Neurologic Clinics. Muscle Disease (dalam bahasa Inggris). 6 (3): 529–544. doi:10.1016/S0733-8619(18)30859-4. ISSN 0733-8619. 
  20. ^ Xiong, Ye; Shie, Feng-Shiun; Zhang, Jing; Lee, Chuan-Pu; Ho, Ye-Shih (2004-05-01). "The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain". Journal of Stroke and Cerebrovascular Diseases (dalam bahasa English). 13 (3): 129–137. doi:10.1016/j.jstrokecerebrovasdis.2004.05.001. ISSN 1052-3057. PMID 17903964. 
  21. ^ "Research day in honor of Dr. Chuan-Pu Lee spotlights Wayne's graduate students". School of Medicine News (dalam bahasa Inggris). 2019-03-08. Diakses tanggal 2022-01-31. 
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